An Autoimmune Disease: Psoriasis

Psoriasis is a common inflammatory skin disease characterized by infiltration of inflammatory cells into the epidermis and altered keratin euclie differentiation psoriasis is the fourth most common skin disease in the United States about 2 in 100 people in America develop psoriasis of some stages of their life. It most commonly starts between the ages of 15 to 25. Possible factors and trigger causing psoriasis include emotional stress, systemic infection and intestinal upset various types of psoriasis have been repeated such as plaque, pseriating flexural psoriasis, pustular psoriasis, Nail psoriasis, erythrodermic psoriasis etc. Various regimes available for psoriasis such as topical agents, phototherapy, systemic agents which help to control the symptoms of psoriasis. About 75% of patients have mild to moderate psoriasis, amenable to topical treatment in lifetime controlling herbal remedies like aloe, cayenne, chamomile, fish oil, flaxseed oil, milk thistle, turmeric, glucosamine etc. are needed. Herbal remedies for the treatment of psoriasis disease to overcome side effect, antagonist effect and bioavailability of the drug. Sethi Reeta* 1 , Paul Yash 1 , Wasil Preeti 1 , Rathi Sudeep 2 , Goyal Surinder 3 1 Lord Shiva College of Pharmacy, Sirsa (Haryana) 2 Wockhdart Limited, Aurangabad (Maharashtra) 3 Vidya Sagar college of Pharmacy, Ahlupur (Punjab), India. Submission: 2 May 2016 Accepted: 7 May 2016 Published: 25 May 2016 www.ijppr.humanjournals.com Citation: Sethi Reeta et al. Ijppr.Human, 2016; Vol. 6 (2): 135-146. 136 INTRODUCTION Psoriasis is regarded as an autoimmune disease in which genetic and environmental factor has a significant role. The name of the disease is derived from a Greek word 'Psora' which means 'itch'. Psoriasis is a non-contagious, dry, inflammatory and ugly skin disorder, which can involve an entire system of person. 1 Psoriasis is a common skin condition which affects men and women of all ages. Skin is made up of millions of tiny skin cells. Normally, skin cells die and are replaced by new ones every three or four weeks. In Psoriasis, body begins upon the skin is raised patches. This is related to an immune response, which is the way in which body fights disease and heals wounds. In psoriasis, an immune system triggers a reaction even though there is no infection or wounds to heal. The reason why it does this are not completely understood but it is mostly caused by variations in your genes. 2 The most commonly affected sites are the scalp, tips of fingers and toes, palms, soles, glutens, under the breasts and genitals, elbows, knees, shins, and sacrum. 3 The severity of psoriasis varies greatly. In some people, it is mild with a few small patches that develop which are barely noticeable. In other words, there are many patches of varying size. In many people, the severity is somewhere between the two extremes. About 2 in 100 people in American develop psoriasis at some stage of their life. It can first develop at any stage, but it most commonly starts between the ages of 15 and 25. On large study also found that smokers have an increased risk of developing psoriasis compared to non-smokers. One theory for this is that toxins (poison) in cigarette smoke may affect part of the immune system involve with psoriasis. 4 This review is a compilation of all aspects regarding psoriasis.